Yes, you can cancel your American Airlines flight and request a refund. If you cancel within 24 hours of booking and your departure is more than two days away, your ticket is fully refundable. For tickets canceled after this period, refund eligibility depends on the fare type and specific cancellation policies. Nonrefundable tickets may be changed or canceled for a travel credit. For assistance, call 1-866-463-2404 to discuss your options and potential fees.